Best Enzyme Drain Cleaners Reviews 2021


Cleaning a carpet or any other fabric is never pleasurable. Oftentimes, when there are stains involved, the stain will almost never go away, especially when it comes to a rug or a carpet. Most of the time, cleaning a stain from any fabric surface with all purpose cleaner or any other type of cleaner that can be bought at a store will not be enough. In some worse cases, it will create a bigger stain. This happens a lot whenever somebody tries to clean a carpet with degreaser, calcium remover, or any other form of all purpose cleaner. Here is a list of five enzyme cleaners that will clean any soft surface safely.

Editor’s Recommendation: 5 Top Enzyme Cleaners

How to choose an enzymatic cleaner ? Characteristics to value before buying

If you have pets you will know the importance of having an effective cleaner that will help you keep your home clean and free from bad odors.

Finding the most suitable one is not always easy and, for this reason, we have prepared a brief guide with some of the characteristics that you should take into account when buying the best enzymatic cleaner.

  1. Enzyme type
  2. Format
  3. Price

Enzyme type

One of the main ingredients that contains an enzymatic cleaner contain a certain type of enzyme depending on the function of the product.

For this reason, if you are looking for an enzymatic cleaner that helps you eliminate waste and odors from your pets, you should look at the composition of its formula and make sure it contains proteases.

best enzymatic cleaner

The proteases are the most indicated to eliminate organic remains such as urine, blood, vomit or feces, so they are essential in a home with pets.


Another characteristic that you should value when buying an enzymatic cleaner is the type of format.

Today, there is a wide variety of enzymatic cleaners with or without spray dispenser.

Depending on whether you are going to apply the product directly on the surface or you are going to dilute it in water, you should choose the first or the second respectively.


Before buying an enzymatic cleaner, you should also assess its price and if it fits your budget.

Therefore, we recommend that you choose the best product also based on your economy.

Remember that there are several enzymatic cleaners on the market, some more expensive and others cheaper.

8 Top Enzyme Cleaners Reviews

1. Rocco & Roxie Professional Strength Stain & Odor Eliminator – Enzyme-Powered Pet Odor & Stain Remover for Dog and Cats Urine

Rocco & Roxie Professional Strength Stain & Odor Eliminator - Enzyme-Powered Pet Odor & Stain Remover for Dog and Cats Urine - Carpet Cleaner Spray - Enzymatic Cat Pee Destroyer - for Small Animals
  • ELIMINATES STAINS, ODORS AND RESIDUE If it’s gross, it’s gone. Not just the stain, but the stink. From stinky yellow pet urine and feces to vomit and other organic spills, our professional...
  • CERTIFIED GENTLE AND SAFE Chlorine free and color safe. Safe to use around pets and children. No hazardous propellants, no residue left behind. So gentle it’s been Certified Safe for all carpets,...

Pets can do some serious damage to a carpet, bed, or any other fabric surface. Urine or any other kind of excrement from a dog or cat usually leave a permanent stain on these kinds of surfaces. And the smell from them usually linger forever. Dealing with this is not pleasurable, and there never seems to be a practical solution. One of the best things about the Rocco and Roxie enzyme cleaner is that it cleans and removes any unpleasant scents where some other enzyme cleaners remove just the stain but are odorless. This means that while the stain is gone, the odor from it will still linger a bit. Another good thing about the Rocco and Roxie enzyme cleaner is that it is not only an all purpose cleaner, it is also an all surface cleaner. It can clean carpets, tile, glass and even concrete. This eliminates the need to have other cleaning solutions in the house.

If you do decide to only keep the Rocco and Roxie enzyme cleaner for all your cleaning needs, be prepared to buy a few bottles, as there is only 32 oz of solution per bottle. This may not be a problem if you are only using it to clean fabrics, but if you plan to use it to clean all surfaces, it will run out quickly. Even for larger homes with larger areas of carpets, 32 oz may not be enough to last a really long time.

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2. Simple Solution Extreme Pet Stain and Odor Remover With Pro-Bacteria and Enzyme Formula, Made in USA

Simple Solution Extreme Pet Stain and Odor Remover | Enzymatic Cleaner with 3X Pro-Bacteria Cleaning Power | 32 Ounces
  • DESIGNED FOR THE TOUGHEST ODORS AND ORGANIC STAINS- Simple Solution pet Extreme Stain and Odor remover is three times stonger than our regular formula to eliminate tough dog and cat odors and stains.
  • PROFESSIONAL STRENGTH FORMULA - Extreme Stain and Odor Remover is a professional strength Pro-Bacteria and enzyme formula that breaks down and eliminates stains and odors.

One thing that many overlook when it comes to pretty much any cleaning solution in a spray bottle is that there is often a need for the bottle to do more than just spray out liquid. Sometimes it is more effective if the solution comes out in foam, or can be sprayed in a stream. While a good amount of enzyme cleaners do not have those kind of options on their spray bottles, the Simple Solution Extreme enzyme cleaner does. This may seem like it is not relevant, but when it comes to spraying down and cleaning carpet stains, it is useful to have a solution to spray as a foam, this way it is easier to clean up stains that may have remained on the carpet for a very long time. This is the best thing about the Simple Solution Extreme enzyme cleaner.

The Simple Solution Extreme enzyme cleaner is good at eliminating stains from a carpet because of the fact that it can spray in the form of mist, foam, or a stream, but it does not perfectly remove odors. It will remove odors enough to where a human nose will not be able to detect them, but if you own a dog, chances are good that the dog will still recognize the odor. This could be a problem as most dogs mark their territory from the smell of their own excrements. Additionally, the Simple Solution Extreme enzyme cleaner works best on carpets, but is not very great at cleaning any other surface. This can be detrimental to some users who want one bottle of cleaner for the entire house.

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3. Nature’s Miracle Dog Stain and Odor Remover, New Odor Control Formula

Nature’s Miracle Stain and Odor Remover Dog, Odor Control Formula
  • SPOT STAIN & ODOR REMOVER: Begins to break down and remove stains immediately on contact.
  • LIGHT CITRUS SCENT: Dog odor control formula gets your home smelling clean again.

Not many enzyme cleaners are effective at cleaning really large stains, at least not in one session. In many cases, it may take many times to clean a large stain with the common enzyme cleaner. The Nature’s Miracle enzyme cleaner is one such cleaner that promises to be able to perfectly clean any stain, no matter how big it may be. It comes with an oxy formula which cleans stains much deeper than other enzyme cleaners. This is the best part about it. Another good thing about the Nature’s Miracle enzyme cleaner is that is has a built in scent which means it can clean a stain and also eliminate its odors.

It appears that the Nature’s Miracle enzyme cleaner does things too well. For example, it does deep clean stains on a carpet or fabric, but oftentimes it will replace the stain with a stain of its own. In addition to this, the Nature’s Miracle enzyme cleaner, while it is scented and can eliminate odors, the scent of it can be too strong and can linger for days. The last thing about the Nature’s Miracle enzyme cleaner that misses the mark is that it takes a long time to settle per session. It takes ten whole minutes to safely blot the stain on the carpet that has been sprayed down. Again, this is likely due to the fact that it cleans deeply and has such a powerful scent.

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4. Simple Solution Pet Stain and Odor Remover with Pro-Bacteria and Enzyme Formula, Made in USA

Simple Solution Pet Stain and Odor Remover | Enzymatic Cleaner with 2X Pro-Bacteria Cleaning Power | 32 Ounces
  • REMOVES PET STAINS- Simple Solution Stain & Odor Remover is formulated to eliminate and neutralize tough dog and cat stains and odors like urine, feces, and vomit
  • UNIQUE PRO-BACTERIA FORMULA - This stain and odor remover has a unique Pro-Bacteria and enzyme formula that eliminates stains and odors, and helps prevent repeat marking

The problem with most heavy duty enzyme cleaners is that it takes way too long for the solution to settle before it is safe to blot it and clean the stain. Not everybody has this kind of time to spend, and there is a demand for a cleaner that can still remove small stains from any fabric, but also saves the user some time. This is what the Simple Solution enzyme cleaner does. Most enzyme cleaners will take about 15 minutes or so to settle before it is safe to blot and clean the stain that it has been sprayed on. With the Simple Solution enzyme cleaner, the wait time is reduced to 10 minutes, and that’s for a larger stain. This is by far the best thing about the Simple solution enzyme cleaner.

The problem with the Simple Solution enzyme cleaner is that all it really does is clean small stains. Because it is not as strong as many other enzyme cleaners, more of it will be necessary to clean larger stains. However, Simple Solution has more powerful enzyme cleaners for those kinds of stains, so if you need to clean larger stains, there is no point in getting this particular bottle of Simple Solution enzyme cleaner when it would be a better choice to get one of their stronger bottles. Another issue is that while it does eliminate odors, the Simple Solution enzyme cleaner itself is odorless, which means that after cleaning a stain with it, you may need to clean over the stain again with an all-purpose cleaner of your choice which does have a scent.

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5. Bubba’s Super Strength Commercial Enzyme Cleaner-Pet Odor Eliminator

BUBBAS Super Strength Commercial Enzyme Cleaner - Pet Odor Eliminator | Enzymatic Stain Remover | Remove Dog Cat Urine Smell from Carpet, Rug or Hardwood Floor and Other Surfaces (Gallon)
  • BEST PROFESSIONAL GRADE CLEANING SOLUTION: Scientifically formulated to be more potent than other pet odor enzyme cleaners for your flooring, upholstery, area rugs and carpets, yet safe to use around...
  • PET STAIN AND ODOR MIRACLE: Bubba's uses natural dormant enzymes that become active upon hitting that strong smelling cat pee, billions of enzymes destroy stains down to the carpet pad. Competitors...

Most people who use enzyme cleaners use them specifically to clean pet stains. They do not consider that they can use enzyme cleaners for many other reasons. Bubba’s enzyme cleaner is one such enzyme cleaner that can clean most everything. It is one of the most heavy duty cleaners that can be found on any market. It can even be used as a pre wash stain treatment for laundry. It cleans any surface and the fact that it comes in a gallon jug means that it can also be used as floor cleaner for when you need to mop the floor. Because it is so powerful, Bubba’s enzyme cleaner is guaranteed to remove odors permanently. If you live in a large area with lots of animals or people who can cause stains, it is a very good idea to get Bubba’s enzyme cleaner.

There are two things about Bubba’s enzyme cleaner that may turn some people off. First, the fact that it only comes in a gallon jug means that it is not really designed for small households or households that would not benefit from keeping a gallon jug of enzyme cleaner. The issue comes when anyone in said household would like just a small bottle of Bubba’s. Getting a small bottle of this enzyme cleaner is not possible. Also, because it is so powerful, it takes much longer to effectively clean a stain than any other enzyme cleaner.

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6. Earth Rated Pet Stain and Odor Remover

Earth Rated Pet Stain and Odor Remover, Lavender-Scented Pet Cleaner for Dog and Cat Urine, 32 fl oz Spray Bottle
  • 🐶 FRIRENDLY FORMULA: This awesome pet cleaner naturally removes urine and other messes left by dogs and cats using friendly ingredients that feed on stains until they’re eliminated completely....
  • 🎯 ON TARGET: Our happy little active ingredients in this pet odor remover are specially selected to target and consume any organic pet mess. This includes anything resulting from your dog’s...

An odor remover with a formula composed of powerful bio enzymes, which work automatically when in contact with urine and feces. This product has the stamp of approval of the Carpet and Rug Institute (CRI) .

This odor eliminator is manufactured in the United States and has a completely safe formula for use in homes with pets and small children, as its composition is completely free of chemicals.

7. OUT Pet Products 70569BR OUT Oxy Stain & Odor Remover

OUT Pet Products 70569BR OUT Oxy Stain & Odor Remover 64 fl. oz.-1.85 ml.
  • Oxidizing power makes pet stains and odors disappear.
  • Removes stains made by urine, vomit, feces, pheromones and blood.

With a formula that leaves all the power of oxygen at your disposal, this odor eliminator can be applied in homes where there are pets and / or small children without generating any type of allergic reaction. Its formula removes the smells of urine, the pheromones found in it, feces and blood.

This product is perfect for use in all areas of the house and thanks to its immediate action all bad odors are completely eliminated automatically.

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8. Particular Paws Triple Action Enzyme Spray Eliminates Dog and Cat Urine

Particular Paws Pet Stain and Odor Remover - Professional Strength Triple Action Enzyme Spray Eliminates Dog and Cat Urine Stains and Smells - 32 oz
  • GET RID OF STAINS OLD AND NEW: Our formula is professional strength, triple action and contains Bio-Enzymes along with helpful bacteria to effectively neutralize odors and get rid of the toughest...
  • ODOR ELIMINATION: Pet stains contain ammonia, stomach acid, and gut flora that give stains their highly unpleasant aroma. Unlike other deodorizers that would just mask the stench, our formula...

A product with an eco-friendly formula based on bio enzymes and mycobacteria, which acts immediately on the area in which it is applied, permanently eliminating the odors of urine, vomit and feces of your pet.

This professional odor eliminator can be applied easily to all areas of the house, and thanks to its chemical-free formula you can use it without the need of a mask or gloves , which makes it very safe for homes with pets and small children.

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Uses of enzyme-based cleaners

After knowing what an enzyme-based cleaner is, let’s find out what are the uses of enzyme-based cleaners. Now you should know, after reading about what an enzyme-based cleaner is, that the cleaning product can be used to clean almost any type of stain.

Bathroom and kitchen

Enzyme-based cleaners can be used to effectively clean the bathroom and kitchen. Cleaners can be used in place of bleach and other harmful cleaning products. The cleaning product can be used to remove stubborn stains in the kitchen sink, countertop, toilet and bathtubs. The best thing about enzyme-based cleaners is that, in addition to removing stains, they also eliminate the odors associated with the stain.


Enzyme-based cleaners can effectively remove stains from clothing. Cleaners can help remove stains from almost every type of clothing. You can use the enzyme-based cleanser to clean stains caused by coffee, chocolate and fat.

Removal of pet urine

Enzyme-based cleaners are also effective as a pet stain cleaner. Cleaners remove stains at the molecular level. They can be used to clean stains on carpets, upholstery and hard floors. The enzymes remove proteins in the pet’s urine. This results in the cleaning of the stain and odor associated with the pet’s urine. Other types of cleaning products only mask the stain without completely removing them. Enzyme-based cleaners, on the other hand, can clean stains quickly and effectively.

Cleans mold

Stains caused by mold are extremely difficult to remove. Stains are not easily removed using cleaning products based on traditional chemicals. Enzyme-based cleaners can clean mold and mildew stains behind the appliance and under the skin. The microorganism can be easily killed when using the enzyme-based cleanser.

One important thing to remember about what an enzyme-based cleanser is is that they can quickly remove stains as they work at the molecular level. Unlike traditional cleaners that can take hours to remove stains, enzyme-based cleaners can remove stains in a matter of minutes. They are extremely safe and effective compared to alternative cleaning products.

Consideration when using enzyme-based cleaners

You should consider certain things when using enzyme-based cleaners. The first thing you should keep in mind regarding enzyme-based cleaners is that you should never expose them to extreme temperatures. Do not expose cleaners to extremely hot or cold temperatures, as they can greatly reduce the effectiveness of cleaners.

You should remember that enzyme-based cleaners should not be left exposed for a long time. The enzymes present in the cleaners have a short life. After diluting the cleaner in water, be sure to use it quickly to clean the stain. Not applying the enzyme-based cleaner shortly after dilution in water may render it ineffective.

Another important thing to keep in mind when it comes to the use of enzyme-based cleaners is that they should be applied directly on the stain. Do not apply the cleaner with a mop or soft cloth to clean the stain. The reason is that the enzyme-based liquid can damage the mop. Instead, you should remove the stain by spraying the enzyme-based liquid on the stain.

Another important thing to keep in mind regarding the use of enzyme-based cleaner is that you should not use a disinfectant after using the enzyme-based cleaner. This can result in an ineffective removal of the stain.

What surfaces can be cleaned with enzyme-based cleaners?

The best thing about enzyme-based cleaners is that they can be used to clean almost any type of surface. Cleaners can be used to clean stains on marble, tile and laminate flooring. Cleaners do not consist of any harmful chemicals. Therefore, they will not damage the floor.

In addition to cleaning the floor, enzyme-based cleaners can also be used effectively to clean fabrics and carpets. The fact is that the cleaners will not make the stain worse. They do not filter the color of clothes in a similar way to certain chemical-based cleaners. That said, before applying the enzyme-based cleaning product, you must first test the product by applying it to a not-so-visible section of the clothing. If the use of the enzyme-based cleaner does not result in the formation of spots, you can use the cleaner safely.


Cleaning stains on the carpet and other fabrics in the house is always going to be stressful. There is no avoiding the fact that it takes some time to clean any given stain in the house, especially if that stain is located on fabric. Enzyme cleaners can reduce the stress in this process by quite a bit. Some enzyme cleaners are stronger than others, and if you use the information about enzyme cleaners above properly, cleaning stains in your fabrics will not be nearly as stressful.

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